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ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

N-Boc-Hexahydro-5-Oxocyclopenta[C]Pyrrole

CAS: 148404-28-8

Molecular Formula: C12H19NO3

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ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate - Names and Identifiers

Name N-Boc-Hexahydro-5-Oxocyclopenta[C]Pyrrole
Synonyms JK841
N-Boc-Hexahydro-5-Oxocyclopenta[C]Pyrrole
N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE
N-Boc-hexahydro-5-oxocyclopenta[C]pyrrole 95％ g 2
Hexahydrocyclopenta[c]pyrrol-5(1H)-one, N-BOC protected
ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
tert-butyl 5-oxo-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
tert-Butyl 5-oxo-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
cis-5-Oxo-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester
cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-oxo-, 1,1-dimethylethyl ester
Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-oxo-, 1,1-diMethylethyl ester
CAS 148404-28-8
InChI InChI=1/C12H19NO3/c1-12(2,3)16-11(15)13-6-8-4-10(14)5-9(8)7-13/h8-9H,4-7H2,1-3H3

ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate - Physico-chemical Properties

Molecular FormulaC12H19NO3
Molar Mass225.28
Density1.139
Boling Point325.8±35.0 °C(Predicted)
Flash Point150.814°C
Vapor Presure0mmHg at 25°C
pKa-0.82±0.20(Predicted)
Storage Condition2-8°C
Refractive Index1.507

ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate - Reference Information

application N-BOC-hexahydro-5-oxocycloprene [C] and pyrrole can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Preparation (1)2,2 '-[1-(tert-butoxy) pyrrolidine -3, 4-diyl] diacetic acid preparation. Dissolve potassium permanganate (1.49g,9.39mmol) in water (15mL), cool to 5 ℃, slowly add 3a,4,7,7a-tetrahydro-1 H-isoindole -2(3H)-tert-butyl formate (700mg,3.13mmol) in acetone (5mL) for 3 hours after adding. Add sodium bisulfite saturated solution to destroy excessive potassium permanganate, adjust the pH to 2 with 1N

HCl, extract with dichloromethane (30mL × 3), wash with saturated salt water (30mL × 3), spin dry to obtain white foam solid 900mg, which is 2,2 '-[1-(tert-butoxy) pyrrolidine -3, 4-diyl] diacetic acid, without purification, proceed directly to the next reaction. (2) Preparation of 5-oxohexahydrocyclopentane [c] pyrrole-2 (1H)-tert-butyl formate. Dissolve 2,2 '-[1-(tert-butoxy) pyrrolidine -3, 4-diyl] diacetic acid (900mg,3.13mmol) in acetic anhydride (15mL), add sodium acetate (231mg,2.82mmol), and react at 120 ℃ for 2 hours. When the reaction liquid is cooled to room temperature, filtered, spin-dried, column chromatography purification (petroleum ether: ethyl acetate = 5:1) to obtain 390mg light yellow oil, which is 5-oxohexahydrocyclopentane [c] pyrrole -2(1H)-tert-butyl formate, two-step yield: 55%.
Last Update：2024-04-10 22:29:15
ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 148404-28-8
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE Visit Supplier Webpage Request for quotation
CAS: 148404-28-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
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